Methylselenol release as a cytotoxic tool: a study of the mechanism of the activity achieved by two series of methylselenocarbamate derivatives-Reference-Cited by-同舟云学术

Methylselenol release as a cytotoxic tool: a study of the mechanism of the activity achieved by two series of methylselenocarbamate derivatives

Published:2018 Issue:8 Volume:10 Page:1128-1140
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Font María¹²³⁴⁵^ORCID,Romano Beatriz¹²³⁶⁵,González-Peñas Elena¹²³⁷⁵^ORCID,Sanmartín Carmen⁸⁹⁵¹⁰¹^ORCID,Plano Daniel⁸⁹⁵¹⁰¹^ORCID,Palop Juan A.¹²³⁶⁵

Affiliation:

1. University of Navarra

2. School of Pharmacy and Nutrition

3. Dpto de Química Orgánica y Farmacéutica

4. Sección de Modelización Molecular

5. Pamplona

6. Sección de Síntesis

7. Sección de Técnicas Instrumentales

8. IdISNA, Instituto de Investigación Sanitaria de Navarra

9. Recinto del Complejo Hospitalario de Navarra

10. Spain

Abstract

Cytotoxic activity is related to the progressive release of active fragments, methylselenol and phenols. The structural variations influence the relative reactivity of the target atoms to the nucleophilic agent, as well as the overall stability and the accessibility to the hydrolysis point.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MT/C8MT00140E

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