Ball milling for the quantitative and specific solvent-free Knoevenagel condensation + Michael addition cascade in the synthesis of various 2-amino-4-aryl-3-cyano-4H-chromenes without heating-Reference-Cited by-同舟云学术

Ball milling for the quantitative and specific solvent-free Knoevenagel condensation + Michael addition cascade in the synthesis of various 2-amino-4-aryl-3-cyano-4H-chromenes without heating

Published:2014 Issue:89 Volume:4 Page:48191-48201
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Qareaghaj Omid Hosseinchi¹²³⁴,Mashkouri Sara¹²³⁴,Naimi-Jamal M. Reza¹²³⁴,Kaupp Gerd⁵²⁶⁷

Affiliation:

1. Research Laboratory of Green Organic Synthesis and Polymers

2. Department of Chemistry

3. Iran University of Science and Technology

4. 16846 Tehran, Iran

5. Faculty 5

6. University of Oldenburg

7. 26188 Edewecht, Germany

Abstract

Various 2-amino-4-aryl-3-cyano-4H-chromenes have been quantitatively prepared by dry ball milling in the presence of catalytic Na₂CO₃. The orientation specificities are discussed; existing misattributions are pointed out and clarified by NMR.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA06603K

Reference76 articles.

1. Solvent-free Knoevenagel condensations and Michael additions in the solid state and in the melt with quantitative yield

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4. Synthesis and pharmacological activity of 2-oxo-(2H) 1-benzopyran-3-carboxamide derivatives

5. Efficient organocatalytic asymmetric synthesis of 2-amino-4H-chromene-3-carbonitrile derivatives

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