Ligand binding effects on the activation of the EGFR extracellular domain-Reference-Cited by-同舟云学术

Ligand binding effects on the activation of the EGFR extracellular domain

Published:2019 Issue:15 Volume:21 Page:8141-8151
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Shao Qiang¹²³⁴⁵^ORCID,Zhu Weiliang¹²³⁴⁵

Affiliation:

1. Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

2. Shanghai

3. China

4. University of Chinese Academy of Sciences

5. Beijing

Abstract

Enhanced sampling MD simulations were run to understand the ligand binding effects on the activation mechanism of EGFR-ECD and accordingly provide valuable information for drug discovery targeting the EGFR.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CP/C8CP07496H

Reference62 articles.

1. ErbB Receptors: Directing Key Signaling Networks Throughout Life

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