Copper binding modulates the platination of human copper chaperone Atox1 by antitumor trans-platinum complexes-Reference-Cited by-同舟云学术

Copper binding modulates the platination of human copper chaperone Atox1 by antitumor trans-platinum complexes

Published:2014 Issue:3 Volume:6 Page:491-497
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Xi Zhaoyong¹²³⁴⁵,Guo Wei⁶⁷⁸⁹¹⁰,Tian Changlin¹¹¹²⁴⁵,Wang Fuyi⁶⁷⁸⁹¹⁰,Liu Yangzhong¹²³⁴⁵

Affiliation:

1. CAS High Magnetic Field Laboratory

2. CAS Key Laboratory of Soft Matter Chemistry

3. Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology

4. University of Science and Technology of China

5. Hefei, China

6. Beijing National Laboratory for Molecular Sciences

7. CAS Key Laboratory of Analytical Chemistry for Living Biosystems

8. Institute of Chemistry

9. Chinese Academy of Sciences

10. Beijing, China

11. Hefei National Laboratory of Microscale Physical Sciences

12. School of Life Science

Abstract

Cu(i) coordination enhances the reactivity of Atox1 towards antitumor-active trans-platinum complexes and promotes platinum transfer from the protein to dithiothreitol.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MT/C3MT00338H

Reference38 articles.

1. Structure, Recognition, and Processing of Cisplatin−DNA Adducts

2. Molecular mechanisms of cisplatin resistance

3. Trans-Platinum Complexes in Cancer Therapy

4. Towards Antitumor Active trans ‐Platinum Compounds

5. Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry?

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