Copper binding modulates the platination of human copper chaperone Atox1 by antitumor trans-platinum complexes

Author:

Xi Zhaoyong12345,Guo Wei678910,Tian Changlin111245,Wang Fuyi678910,Liu Yangzhong12345

Affiliation:

1. CAS High Magnetic Field Laboratory

2. CAS Key Laboratory of Soft Matter Chemistry

3. Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology

4. University of Science and Technology of China

5. Hefei, China

6. Beijing National Laboratory for Molecular Sciences

7. CAS Key Laboratory of Analytical Chemistry for Living Biosystems

8. Institute of Chemistry

9. Chinese Academy of Sciences

10. Beijing, China

11. Hefei National Laboratory of Microscale Physical Sciences

12. School of Life Science

Abstract

Cu(i) coordination enhances the reactivity of Atox1 towards antitumor-active trans-platinum complexes and promotes platinum transfer from the protein to dithiothreitol.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

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