Emerging mRNA technologies: delivery strategies and biomedical applications

Author:

Xiao Yufen1,Tang Zhongmin1,Huang Xiangang1ORCID,Chen Wei1,Zhou Jun1,Liu Haijun1,Liu Chuang1ORCID,Kong Na21,Tao Wei1ORCID

Affiliation:

1. Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA

2. Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang 311121, China

Abstract

This review highlights significant progress in mRNA delivery platforms and therapeutic applications from the view of chemistry. Insights into the challenges and future development towards clinical translation of mRNA therapeutics are also provided.

Funder

Harvard Medical School

American Heart Association

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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