Probing the mechanism for hydrogel-based stasis induction in human pluripotent stem cells: is the chemical functionality of the hydrogel important?-Reference-Cited by-同舟云学术

Probing the mechanism for hydrogel-based stasis induction in human pluripotent stem cells: is the chemical functionality of the hydrogel important?

Published:2020 Issue:1 Volume:11 Page:232-240
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sponchioni M.¹²³⁴^ORCID,O'Brien C. T.¹²³⁴,Borchers C.¹²³⁴,Wang E.⁵⁶⁷⁸,Rivolta M. N.⁹²³⁴^ORCID,Penfold N. J. W.¹²³⁴^ORCID,Canton I.¹²³⁴,Armes S. P.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Sheffield

3. Sheffield

4. UK

5. Department of Biochemistry and Molecular Genetics

6. University of Louisville

7. Louisville

8. USA

9. Department of Biomedical Science

Abstract

It is shown that hydroxyl functionality is required to induce stasis in human embryonic stem cell colonies immersed within wholly synthetic block copolymer worm gels with comparable storage moduli. Thus gel softness does not appear to be an essential parameter for stasis induction.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC04734D

Reference78 articles.

1. Embryonic Stem Cell Lines Derived from Human Blastocysts

2. Clonally Derived Human Embryonic Stem Cell Lines Maintain Pluripotency and Proliferative Potential for Prolonged Periods of Culture

3. Differentiation of Human Embryonic Stem Cells Occurs through Symmetric Cell Division