Synthesis of hybrids thiazole–quinoline, thiazole–indole and their analogs: in vitro anti-proliferative effects on cancer cell lines, DNA binding properties and molecular modeling-Reference-Cited by-同舟云学术

Synthesis of hybrids thiazole–quinoline, thiazole–indole and their analogs: in vitro anti-proliferative effects on cancer cell lines, DNA binding properties and molecular modeling

Published:2021 Issue:31 Volume:45 Page:13847-13859
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Santos-Junior Paulo Fernando da S.¹²³⁴⁵,Nascimento Igor José dos S.¹²³⁴⁵,da Silva Edjan Carlos D.¹²³⁴⁵,Monteiro Kadja Luana C.¹²³⁴⁵,de Freitas Johnnatan D.⁶⁷⁴⁵,de Lima Lins Samaysa⁸⁹³⁴⁵,Maciel Thamilla Maria S.¹⁰⁹³⁴⁵,Cavalcanti Bruno C.¹¹¹²¹³¹⁴¹⁵,V. Neto José de Brito¹¹¹²¹³¹⁴¹⁵,de Abreu Fabiane C.⁸⁹³⁴⁵,Figueiredo Isis M.¹⁰⁹³⁴⁵,Carinhanha C. Santos Josué¹⁰⁹³⁴⁵^ORCID,Pessoa Claudia do Ó¹¹¹²¹³¹⁴¹⁵,da Silva-Júnior Edeildo F.¹²³⁴⁵,de Araújo-Júnior João X.¹²³⁴⁵,M. de Aquino Thiago¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Medicinal Chemistry

2. Institute of Pharmaceutical Sciences

3. Federal University of Alagoas-UFAL

4. Maceió

5. Brazil

6. Instrumental Analysis Laboratory

7. Federal Institute of Alagoas-IFAL

8. Laboratory of Electrochemistry and Microsystems for Analysis

9. Institute of Chemistry and Biotechnology

10. Laboratory of Instrumentation and Development in Analytical Chemistry

11. Drug Research and Development Center-NPDM

12. Department of Physiology and Pharmacology

13. Faculty of Medicine

14. Federal University of Ceará-UFC

15. Fortaleza

Abstract

A quinoline–thiazole hybrid was synthesized, which showed cytotoxicity against the HL-60 cell line. Electrochemical and spectroscopic experiments suggested DNA as the biological target.

Funder

Fundação de Amparo à Pesquisa do Estado de Alagoas

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ02105B

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1. Paleo-oncology in the Dakhleh Oasis, Egypt: Case studies and a paleoepidemiological perspective