Lubricin (PRG-4) anti-fouling coating for surface-enhanced Raman spectroscopy biosensing: towards a hierarchical separation system for analysis of biofluids

Author:

Han Mingyu123ORCID,Silva Saimon M.425ORCID,Russo Matthew J.1,Desroches Pauline E.1,Lei Weiwei1ORCID,Quigley Anita F.26,Kapsa Robert M. I.26,Moulton Simon E.425,Stoddart Paul R.7ORCID,Greene George W.142

Affiliation:

1. Institute for Frontier Materials, Deakin University, Waurn Ponds, Victoria 3216, Australia

2. The Aikenhead Centre for Medical Discovery, St Vincent's Hospital Melbourne, Fitzroy, Victoria 3065, Australia

3. Commonwealth Scientific and Industrial Research Organization (CSIRO), Agriculture and Food, 671 Sneydes Road, Werribee, Victoria, 3030, Australia

4. ARC Centre of Excellence for Electromaterials Science, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia

5. Iverson Health Innovation Research Institute, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia

6. School of Electrical and Biomedical Engineering, RMIT University, Melbourne, Victoria 3001, Australia

7. School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia

Abstract

A fouling-resistant SERS sensor was demonstrated, enabled by the anti-adhesive and size-selective transport properties of self-assembled lubricin brushes. R6G was successfully identified in unprocessed whole blood using LUB-SERS.

Funder

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference79 articles.

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3. Surface-Enhanced Raman Spectroscopy for Bioanalysis: Reliability and Challenges

4. Review of Surface Enhanced Raman Scattering Applications in Forensic Science

5. Development of surface-enhanced Raman spectroscopy application for determination of illicit drugs: Towards a practical sensor

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