Extraction optimization using Box–Behnken design and method validation for ethanol in oral fluid

Author:

Santos Maíra Kerpel dos12345,Borille Bruna Tassi12345,Cruz Giuliano Netto Flores12345,Coppe Bruna Claudia12345,Comiran Eloisa12345,Kaiser Samuel12345,Fröehlich Pedro Eduardo12345,Limberger Renata Pereira12345

Affiliation:

1. Postgraduate Program in Pharmaceutical Sciences

2. Toxicology Laboratory

3. School of Pharmacy

4. Federal University of Rio Grande do Sul

5. Porto Alegre, Brazil

Abstract

An optimization was proposed for the extraction of ethanol from oral fluid (OF) using the headspace (HS) technique, through experimental design and subsequent development and validation of an analytical method using HS-GC/FID and HS-GC/MS.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Reference31 articles.

1. R. P. Limberger , P. E.Fröehlich , P. O.Boehl , D. Z.Souza , I.Zancanaro , K. C.Mariotti , E.Comiran , D. S.Prusch and F.Oliveira , in The National Policy on Drugs , ed. F. Pechansky , P. C. V. Arruda and R. B. De Boni , Porto Alegre , 2010 , pp. 40–47

2. Instituto de Pesquisa Econômica Aplicada, Impactos sociais e econômicos dos acidentes de trânsito nas rodovias brasileiras, available at http://www.ipea.gov.br , accessed October 2012

3. T. Sousa , E.Correa , M. Z.Stampe , S. S.P Junior and R. B.De Boni , in The National Policy on Drugs , ed. F. Pechansky , P. C. V. Arruda and R. B. De Boni , Porto Alegre , 2010 , pp.100–111

4. Brasil, Conselho Nacional de Trânsito, Resolução no. 432 de 23 de janeiro de 2013, Brasília, Brasil, available at http://www.denatran.gov.br/resolucoes.htm , 2013, accessed January 2013

5. Young people's blood alcohol concentration and the alcohol consumption city law, Brazil

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3