A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion-Reference-Cited by-同舟云学术

A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion

Published:2016 Issue:47 Volume:7 Page:7204-7210
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Heath Felicity¹²³,Newman Amy¹²³,Clementi Chiara⁴⁵⁶⁷⁸,Pasut Gianfranco⁴⁵⁶⁷⁸,Lin Hong¹²³,Stephens Gary J.¹²³,Whalley Benjamin J.¹²³,Osborn Helen M. I.¹²³,Greco Francesca¹²³

Affiliation:

1. Reading School of Pharmacy

2. Reading

3. UK

4. Dept. of Pharmaceutical Sciences

5. Via F. Marzolo 5

6. University of Padua

7. Padova

8. Italy

Abstract

A PEG–haloperidol conjugate was synthesised, which retains binding to the dopamine D₂receptor, showing the possibility of using polymer-drug conjugates as drugsper se' rather than as prodrugs.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2016/PY/C6PY01418F

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1. Treatment of Parkinsonism with L-Dopa and a Decarboxylase Inhibitor

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