Transition metal-free domino acyl substitution/Michael addition of alkenyl Grignard reagents to lactam esters: synthesis of lactam-bearing homoallylic ketones-Reference-Cited by-同舟云学术

Transition metal-free domino acyl substitution/Michael addition of alkenyl Grignard reagents to lactam esters: synthesis of lactam-bearing homoallylic ketones

Published:2020 Issue:38 Volume:10 Page:22454-22459
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Farah Abdikani Omar¹²³⁴,Rabah Muhannad¹²³⁴,Beng Timothy K.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Central Washington University

3. Ellensburg

4. USA

Abstract

A solvent-controlled and heteroatom-dictated protocol for the transition metal-free addition of alkenyl Grignard reagents to lactam esters has been developed, leading to the chemo- and regioselective synthesis of lactam-tethered homoallylic ketones.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA03885G

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