Parallel motif triplex formation via a new, bi-directional hydrogen bonding pattern incorporating a synthetic cyanuryl nucleoside into the sense chain
Author:
Affiliation:
1. Department of Chemistry
2. Shibaura Institute of Technology
3. Saitama-City
4. Japan
5. Department of Life and Environmental Sciences
6. Faculty of Engineering
7. Chiba Institute of Technology
8. Narashino
Abstract
The triplex formation ability of a sense chain containing a cyanuryl nucleoside was evaluated and the tertiary structure of the triplex was calculated using the NOE in 1H NMR by incorporating a 15N into the base moiety.
Funder
Promotion and Mutual Aid Corporation for Private Schools of Japan
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA03889J
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1. FORMATION OF A THREE-STRANDED POLYNUCLEOTIDE MOLECULE
2. Sequence-specific recognition, photocrosslinking and cleavage of the DNA double helix by an oligo-(α]-thymidylate covalently linked to an azidoproflavine derivative
3. Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation
4. Triplex-directed modification of genes and gene activity
5. Triplex DNA: fundamentals, advances, and potential applications for gene therapy
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