Formal total synthesis of salvianolic acid N
Author:
Affiliation:
1. College of Pharmaceutical Science
2. Zhejiang University of Technology
3. Hangzhou 310014
4. China
5. School of Pharmaceutical Sciences
6. Zhejiang University
7. Hangzhou 310058
Abstract
Salvianolic acid N was synthesized starting from 3,4-dimethoxybenzaldehyde in 11 steps and with an overall yield of 11%. The key reaction steps were the Wittig reaction for Z-stereoselectivity, the copper catalyzed intramolecular cyclization for seven membered ring skeleton, and the deprotected allylic group with Pd catalysis.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB03025H
Reference33 articles.
1. Iridoid-related aglycone and its glycosides from Scrophularia ningpoensis
2. Two New Abietane Diterpenoids fromSalvia yunnanensis
3. Active ingredients in Chinese medicines promoting blood circulation as Na+/K+-ATPase inhibitors
Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Neuroprotection induced by salvianolic acids;Natural Molecules in Neuroprotection and Neurotoxicity;2024
2. Recent Advances on the Development of Synthetic Strategies to Access Dibenzoxepine Derivatives;Synthesis;2022-09-27
3. Exciting progress in the transition metal‐catalyzed synthesis of oxepines, benzoxepines, dibenzoxepines, and other derivatives;Applied Organometallic Chemistry;2021-12-28
4. One-Step Synthesis of Triphenylphosphonium Salts from (Het)arylmethyl Alcohols;The Journal of Organic Chemistry;2021-07-07
5. Total Synthesis of Oxepin and Dihydrooxepin Containing Natural Products;Synthesis;2021-06-24
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3