Amide phosphonium salt catalyzed enantioselective Mannich addition of isoxazole-based nucleophiles to β,γ-alkynyl-α-ketimino esters-Reference-Cited by-同舟云学术

Amide phosphonium salt catalyzed enantioselective Mannich addition of isoxazole-based nucleophiles to β,γ-alkynyl-α-ketimino esters

Published:2022 Issue:16 Volume:20 Page:3323-3334
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Gu Congzheng¹,Tian Guangzheng¹,Yin Qingyu¹,Wu Fan¹,Li Zhiming¹,Wu Xiaoyu¹^ORCID

Affiliation:

1. Center for Supramolecular Chemistry and Catalysis and Department of Chemistry, College of Sciences, Shanghai University, 99 Shangda Lu, Shanghai 200444, People's Republic of China

Abstract

Using 5 mol% of a phosphonium salt catalyst derived from a chiral amino alcohol, the enantioselective Mannich addition of 3,5-disubstituted 4-nitroisoxazoles to β,γ-alkynyl-α-ketimino esters has been developed.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00309K

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1. Lithium Alkoxides of Cinchona Alkaloids as Chiral Controllers for Enantioselective Acetylide Addition to Cyclic N-Acyl Ketimines

2. An Efficient Chiral Moderator Prepared from Inexpensive (+)-3-Carene: Synthesis of the HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor DPC 963

3. Substrate Activity Screening: A Fragment-Based Method for the Rapid Identification of Nonpeptidic Protease Inhibitors