Epigallocatechin gallate-zinc oxide co-crystalline nanoparticles as an anticancer drug that is non-toxic to normal cells

Author:

Samutprasert Pawatsanai12345,Chiablaem Khajeelak6784,Teeraseranee Chanon91034,Phaiyarin Punnawich1234,Pukfukdee Puttikorn1234,Pienpinijtham Prompong1234ORCID,Svasti Jisnuson6784,Palaga Tanapat1123412,Lirdprapamongkol Kriengsak6784,Wanichwecharungruang Supason123412ORCID

Affiliation:

1. Department of Chemistry

2. Faculty of Science

3. Chulalongkorn University

4. Thailand

5. Center of Excellence on Petrochemical and Materials Technology

6. Laboratory of Biochemistry

7. Chulabhorn Research Institute

8. Bangkok 10210

9. Department of Nanoengineering

10. Faculty of Engineering

11. Department of Microbiology

12. Center of Excellence on Materials and Bio-interfaces

Abstract

A tea polyphenol, epigallocatechin-3-gallate (EGCG), can enhance cytotoxicity of Zinc in cancer cells. Here we synthesize hybrid EGCG-ZnO nanoparticles that can kill PC-3 prostate cancer cells at concentrations that are not toxic to normal cells.

Funder

Chulalongkorn University

Chulabhorn Research Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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