Smurf1-targeting miR-19b-3p-modified BMSCs combined PLLA composite scaffold to enhance osteogenic activity and treat critical-sized bone defects

Author:

Xiong Ao12345ORCID,He Yijun6784,Gao Liang9101112,Li Guoqing12345,Weng Jian12345,Kang Bin12345ORCID,Wang Deli12345,Zeng Hui12345

Affiliation:

1. Department of Bone & Joint Surgery

2. Peking University Shenzhen Hospital

3. Shenzhen

4. PR China

5. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials

6. Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University

7. The Third Affiliated Hospital of Guangzhou Medical University

8. Guangzhou

9. Center of Experimental Orthopaedics

10. Saarland University Medical Center

11. Homburg

12. Germany

Abstract

Over the past few years, tissue-engineering technology provided a new direction for bone defects therapy, which involved developing applicable biological materials composite with seed cells to repair bone defects tissue.

Funder

Sanming Project of Medicine in Shenzhen

Natural Science Foundation of Guangdong Province

Shenzhen Research and Development Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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