Acrylic-based culture plate format perfusion device to establish liver endothelial–epithelial interface

Author:

McDuffie Dennis1,Alver Charles G.1,Suthar Bhumi1,Helm Madeline1,Oliver David1,Burgess R. Alan2,Barr David2,Thomas Emmanuel23,Agarwal Ashutosh134ORCID

Affiliation:

1. Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA

2. Department of Pathology & Laboratory Medicine, Schiff Center for Liver Diseases, University of Miami Miller School of Medicine, Miami, FL, USA

3. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, USA

4. Desai Sethi Urology Institute, University of Miami Miller School of Medicine, USA

Abstract

Mimicking hepatic acinus architecture and physiological function within a modular Liver on a Chip has a profound effect on hepatocyte function, and motivates future study of multi-organ interactions.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of General Medical Sciences

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Reference31 articles.

1. Microfluidic organs-on-chips

2. B.Alberts , A.Johnson , J.Lewis , M.Raff , K.Roberts and P.Walter , Molecular Biology of the Cell , Garland Science , New York , 4th edn, 2022 , Available from: https://www.ncbi.nlm.nih.gov/books/NBK21054

3. The Vascular Endothelium and Human Diseases

4. PDMS microfluidics: A mini review

5. PDMS-based microfluidic devices for biomedical applications

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