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Small molecules DNAmethyltransferasesinhibitors

Published:2012 Issue:3 Volume:3 Page:263-273
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Martinet Nadine¹²³⁴⁵,Michel Benoît Y.¹²³⁴⁵,Bertrand Philippe⁶⁷⁸,Benhida Rachid¹²³⁴⁵

Affiliation:

1. Laboratoire de Chimie des Molécules Bioactives et des Arômes

2. UMR 6001 CNRS

3. Institut de Chimie de Nice

4. Université de Nice-Sophia Antipolis

5. 06108 Nice Cedex 2

6. Laboratory of reactivity and synthesis of natural substances

7. UMR 6514 Poitiers

8. France

Abstract

This review describes current knowledge concerning DNA methyltransferases (DNMT) biology and the two main classes of DNMT inhibtors.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2012/MD/C1MD00194A

Reference111 articles.

1. Cytosine methylation alters DNA mechanical properties

2. Activation du génome embryonnaire

3. Genomic imprinting: the emergence of an epigenetic paradigm

4. Genetics and epigenetics of the X chromosome

5. High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer

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