Evaluation of novel N′-(3-hydroxybenzoyl)-2-oxo-2H-chromene-3-carbohydrazide derivatives as potential HIV-1 integrase inhibitors-Reference-Cited by-同舟云学术

Evaluation of novel N′-(3-hydroxybenzoyl)-2-oxo-2H-chromene-3-carbohydrazide derivatives as potential HIV-1 integrase inhibitors

Published:2019 Issue:1 Volume:10 Page:80-88
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Jesumoroti Omobolanle J.¹²³⁴^ORCID,Faridoon Faridoon¹²³⁴^ORCID,Mnkandhla Dumisani⁵²³⁴⁶^ORCID,Isaacs Michelle⁵²³⁴⁶,Hoppe Heinrich C.⁵²³⁴⁶^ORCID,Klein Rosalyn¹²³⁴⁶^ORCID

Affiliation:

1. Department of Chemistry

2. Rhodes University

3. Grahamstown

4. South Africa

5. Department of Biochemistry and Microbiology

6. Centre for Chemico- and Biomedicinal Research

Abstract

In an attempt to identify potential new agents that are active against HIV-1 IN, a series of novel coumarin-3-carbohydrazide derivatives were designed and synthesised.

Funder

South African Medical Research Council

Organization for Women in Science for the Developing World

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C8MD00328A

Reference28 articles.

1. HIV-1 integrase: the next target for AIDS therapy?

2. Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)