Perspective of structural flexibility on selective inhibition towards CYP1B1 over CYP1A1 by α-naphthoflavone analogs-Reference-Cited by-同舟云学术

Perspective of structural flexibility on selective inhibition towards CYP1B1 over CYP1A1 by α-naphthoflavone analogs

Published:2021 Issue:36 Volume:23 Page:20230-20246
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Wang Ying¹^ORCID,Hu Baichun²³^ORCID,Zhang Yupeng¹,Wang Dong¹^ORCID,Luo Zhaohu¹^ORCID,Wang Jian²³^ORCID,Zhang Fengjiao¹^ORCID

Affiliation:

1. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

2. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

3. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

Abstract

The structural flexibility of protein domains mainly orchestrated the sustainability of crucial π–π stacking interactions with the key phenylalanine residues of CYP1A1 and CYP1B1, thereby determining the inhibitory selectivity towards CYP1B1.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D1CP02541D

Reference39 articles.

1. The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis

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3. Polycyclic Aromatic Hydrocarbons: From Metabolism to Lung Cancer

4. Oral Benzo[a]pyrene in Cyp1 Knockout Mouse Lines: CYP1A1 Important in Detoxication, CYP1B1 Metabolism Required for Immune Damage Independent of Total-Body Burden and Clearance Rate

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