A doxorubicin–peptide–gold nanoparticle conjugate as a functionalized drug delivery system: exploring the limits-Reference-Cited by-同舟云学术

A doxorubicin–peptide–gold nanoparticle conjugate as a functionalized drug delivery system: exploring the limits

Published:2022 Issue:24 Volume:24 Page:14985-14992
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Exner Kai S.¹²^ORCID,Ivanova Anela¹^ORCID

Affiliation:

1. Sofia University, Faculty of Chemistry and Pharmacy, Department of Physical Chemistry, 1 James Bourchier blvd., 1164 Sofia, Bulgaria

2. Cluster of Excellence RESOLV, Bochum, Germany

Abstract

We model by classical MD and DFT a drug delivery system component for the cytostatic doxorubicin. The prototype DDS is a gold nanoparticle, surface-grafted with a drug-binding peptide and guidelines are provided for enhancing its delivery efficiency.

Funder

Deutsche Forschungsgemeinschaft

Alexander von Humboldt-Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP00707J

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