Design, synthesis, and antiproliferative screening of new quinoline derivatives bearing a <i>cis</i>-vinyl triamide motif as apoptosis activators and EGFR-TK inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, and antiproliferative screening of new quinoline derivatives bearing a cis-vinyl triamide motif as apoptosis activators and EGFR-TK inhibitors

Published:2024 Issue:34 Volume:14 Page:24781-24790
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Abd El-Lateef Hany M.¹²,Ahmed Gaafar Ahmed Gaafar³,Alqahtani Arwa Sultan⁴,Al-Mutairi Aamal A.⁴,Alshaya Dalal Sulaiman⁵,Elsaid Fahmy Gad⁶,Fayad Eman⁷,Farouk N. A.⁸^ORCID

Affiliation:

1. Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia

2. Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt

3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Port Said University, Port Said, Egypt

4. Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University(IMSIU), P.O. Box 90950, Riyadh 11623, Saudi Arabia

5. Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia

6. Department of Biology, College of Science, King Khalid University, PO Box 960, Abha, 61421, Asir, Saudi Arabia

7. Department of Biotechnology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

8. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt

Abstract

A set of novel quinoline tethered cis-vinyl triamides derivatives has been designed, synthesized and screened for in vitro cytotoxicity against the MCF-7 breast adenocarcinoma cell line.

Funder

King Faisal University

Princess Nourah Bint Abdulrahman University

King Khalid University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA04915B

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