Integration of transcriptomics and metabolomics to reveal the effect of ginsenoside Rg3 on allergic rhinitis in mice-Reference-Cited by-同舟云学术

Integration of transcriptomics and metabolomics to reveal the effect of ginsenoside Rg3 on allergic rhinitis in mice

Published:2023 Issue:5 Volume:14 Page:2416-2431
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Liu Jianming¹,Yang Na²,Yi Xingcheng³,Wang Guoqiang⁴,Wang Cuizhu⁵,Lin Hongqiang⁴,Sun Liwei¹,Wang Fang⁴,Zhu Dongdong¹⁶^ORCID

Affiliation:

1. Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun 130021, China

2. Clinical Pharmacy Department, First Hospital of Jilin University, Changchun 130021, China

3. Laboratory of Cancer Precision Medicine, First Hospital of Jilin University, Changchun 130061, China

4. Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China

5. School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China

6. Jilin Provincial Key Laboratory of Precise Diagnosis and Treatment of Upper Airway Allergic Diseases, Changchun 130021, China

Abstract

Ginsenoside Rg3 has a protective effect against AR. The gene-metabolite network that played the main role in AR mice under Rg3 treatment has been explored by the integrated metabolomic and transcriptomic strategy.

Funder

Natural Science Foundation of Jilin Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO03885D

Reference83 articles.

1. Anti-Asthmatic Effects of Ginsenoside Rb1 in a Mouse Model of Allergic Asthma Through Relegating Th1/Th2

2. Fermented red ginseng and ginsenoside Rd alleviate ovalbumin-induced allergic rhinitis in mice by suppressing IgE, interleukin-4, and interleukin-5 expression

3. Ginsenoside Rg1 inhibits the TSLP production in allergic rhinitis mice

4. Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice

5. Ginsenoside Rh1 attenuates ovalbumin-induced asthma by regulating Th1/Th2 cytokines balance

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