Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes – synthesis and COX-2 inhibition activity-Reference-Cited by-同舟云学术

Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes – synthesis and COX-2 inhibition activity

Published:2018 Issue:3 Volume:9 Page:534-544
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Roscales Silvia¹²³⁴⁵^ORCID,Bechmann Nicole¹²³⁴⁵^ORCID,Weiss Daniel Holger⁶⁷⁸⁹⁵,Köckerling Martin⁶⁷⁸⁹⁵^ORCID,Pietzsch Jens¹²³⁴⁵^ORCID,Kniess Torsten¹²³⁴⁵^ORCID

Affiliation:

1. Department of Radiopharmaceutical and Chemical Biology

2. Helmholtz-Zentrum Dresden-Rossendorf

3. Institute of Radiopharmaceutical Cancer Research

4. 01328 Dresden

5. Germany

6. Department of Inorganic Solid State Chemistry

7. Institute of Chemistry

8. University of Rostock

9. 18059 Rostock

Abstract

By Ru(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes 3,4-diaryl-substituted isoxazoles are formed in one step, showing high inhibition potency for COX-2.

Funder

Ramón Areces Foundation

European Social Fund

Helmholtz Association

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C7MD00575J

Reference45 articles.

1. Cyclooxygenase Enzymes: Regulation and Function