Towards the stable chelation of radium for biomedical applications with an 18-membered macrocyclic ligand-Reference-Cited by-同舟云学术

Towards the stable chelation of radium for biomedical applications with an 18-membered macrocyclic ligand

Published:2021 Issue:10 Volume:12 Page:3733-3742
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Abou Diane S.¹²³⁴⁵^ORCID,Thiele Nikki A.⁶⁷⁸⁴⁹^ORCID,Gutsche Nicholas T.¹⁰¹¹¹²¹³¹⁴,Villmer Alexandria¹²³⁴⁵,Zhang Hanwen¹²³⁴⁵^ORCID,Woods Joshua J.⁶⁷⁸⁴¹⁵^ORCID,Baidoo Kwamena E.¹⁰¹¹¹²¹³¹⁴,Escorcia Freddy E.¹⁰¹¹¹²¹³¹⁴^ORCID,Wilson Justin J.⁶⁷⁸⁴^ORCID,Thorek Daniel L. J.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Radiology

2. Washington University in St. Louis School of Medicine

3. St. Louis

4. USA

5. Program in Quantitative Molecular Therapeutics

6. Department of Chemistry and Chemical Biology

7. Cornell University

8. Ithaca

9. Chemical Sciences Division

10. Molecular Imaging Program

11. Center for Cancer Research

12. National Cancer Institute

13. National Institutes of Health

14. Bethesda

15. Robert F. Smith School for Chemical and Biomolecular Engineering

Abstract

The therapeutic alpha-emitter ²²³Ra can be stably complexed in vivo, creating opportunities for the development of targeted radiopharmaceutical agents with this radionuclide.

Funder

National Institute of Biomedical Imaging and Bioengineering

Division of Chemistry

National Cancer Institute

Research Corporation for Science Advancement

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC06867E

Reference59 articles.