Light-triggered dual-modality drug release of self-assembled prodrug-nanoparticles for synergistic photodynamic and hypoxia-activated therapy-Reference-Cited by-同舟云学术

Light-triggered dual-modality drug release of self-assembled prodrug-nanoparticles for synergistic photodynamic and hypoxia-activated therapy

Published:2020 Issue:5 Volume:5 Page:886-894
ISSN:2055-6756
Container-title:Nanoscale Horizons
language:en
Short-container-title:Nanoscale Horiz.

Author:

Zhao Dongyang¹²³⁴⁵,Tao Wenhui¹²³⁴⁵,Li Songhao¹²³⁴⁵,Li Lingxiao¹²³⁴⁵,Sun Yixin¹²³⁴⁵,Li Guanting¹²³⁴⁵,Wang Gang⁶⁷⁸⁵,Wang Yang⁶⁷⁸⁵,Lin Bin⁹³⁴⁵,Luo Cong¹²³⁴⁵,Wang Yongjun¹²³⁴⁵,Cheng Maosheng⁹³⁴⁵,He Zhonggui¹²³⁴⁵,Sun Jin¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutics

2. Wuya College of Innovation

3. Shenyang Pharmaceutical University

4. Shenyang 110016

5. China

6. College of Pharmacy

7. Guangxi University of Chinese Medicine

8. Nanning 530200

9. Key Laboratory of Structure-Based Drug Design and Discovery

Abstract

Prodrug-nanoparticles turn the disadvantage of the aggregation-caused quenching effect into an advantage to promote dual-modality PR104A release. Besides, photodynamic therapy-induced hypoxia activates PR104A for high-efficiency synergistic therapy.

Funder

National Natural Science Foundation of China

Department of Education of Liaoning Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NH/D0NH00034E

Reference33 articles.

1. Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

2. Tumor hypoxia: its impact on cancer therapy

3. Covalent Organic Polymers Based on Fluorinated Porphyrin as Oxygen Nanoshuttles for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy

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