A model for N-to-C direction in prebiotic peptide synthesis

Author:

Zhang Li1,Zhang Min1,Guo Xiaofan1,Gan Dingwei2,Ye Yong3,Zhao Yufen14ORCID,Ying Jianxi1ORCID

Affiliation:

1. Institute of Drug Discovery Technology, Ningbo University, No. 818 Fenghua Road, Ningbo, Zhejiang 315211, China

2. School of Electrical Engineering, Xi'an Jiaotong University, No. 28 Xianning West Road, China

3. College of Chemistry, Zhengzhou University, Zhengzhou 450001, China

4. College of Chemistry and Chemical Engineering, Xiamen University, No. 422, China

Abstract

Prebiotic peptide synthesis achieves directional extension from N to C by starting with Ac-AA-NH2 as the N-terminal substrate and using AA-NH2 as the building block of the C-terminal extension.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Natural Science Foundation of Henan Province

Publisher

Royal Society of Chemistry (RSC)

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