Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity-Reference-Cited by-同舟云学术

Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity

Published:2023 Issue:4 Volume:14 Page:782-789
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Gannett Cole¹²^ORCID,Banks Paige¹,Chuong Christina³²,Weger-Lucarelli James³²,Mevers Emily¹²⁴,Lowell Andrew N.¹²⁴^ORCID

Affiliation:

1. Department of Chemistry, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA 24061, USA

2. Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA 24061, USA

3. Department of Biomedical Sciences and Pathobiology, VA-MD Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA 24061, USA

4. Faculty of Health Sciences, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA 24061, USA

Abstract

A potential rich source of new antimicrobials is undeveloped natural product cytotoxins. We used semisynthesis to derivatize the neglected antibiotic blasticidin S, creating ester derivatives with enhanced selectivity for bacteria.

Funder

Virginia Polytechnic Institute and State University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00412G

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