Oligomeric procyanidins inhibit insulin fibrillation by forming unstructured and off-pathway aggregates-Reference-Cited by-同舟云学术

Oligomeric procyanidins inhibit insulin fibrillation by forming unstructured and off-pathway aggregates

Published:2021 Issue:59 Volume:11 Page:37290-37298
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Chen Shaohuang¹,Yin Huiting¹,Zhang Lei¹,Liu Rui²,Qi Wei¹,He Zhimin¹,Su Rongxin¹³^ORCID

Affiliation:

1. State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

2. State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, China

3. School of Marine Science and Technology, Tianjin University, Tianjin 300072, China

Abstract

Effects of natural polyphenols on insulin fibrillation were compared. OPCs show potent inhibitory effects at all stages of insulin fibrillation and redirect the insulin aggregation pathway via the formation of unstructured, off-pathway aggregates.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA05397C

Reference46 articles.

1. O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity

2. Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life