Ultrafast dynamics of the antibiotic Rifampicin in solution
Author:
Affiliation:
1. Departamento de Química Física
2. Facultad de Ciencias Ambientales y Bioquímica and INAMOL
3. Universidad de Castilla-La Mancha
4. 45071 Toledo
5. Spain
Abstract
Ultrafast time-resolved studies demonstrate that intra- and intermolecular H-bonds with water molecules act synergistically to stabilize the active zwitterionic form of Rifampicin, an effective antibiotic against mycobacterial infections.
Funder
FP7 People: Marie-Curie Actions
Secretaría de Estado de Investigación, Desarrollo e Innovación
Publisher
Springer Science and Business Media LLC
Subject
Physical and Theoretical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/PP/C8PP00192H
Reference66 articles.
1. F. Parenti and G.Lancini , in Antibiotic and Chemotherapy , ed. D. Greenwood , S. R. Norrby and R. J. Whitley , Content Repository Only! , London , 9th edn, 2010 , pp. 326–333 , 10.1016/B978-0-7020-4064-1.00027-0
2. RifamycinMode of Action, Resistance, and Biosynthesis
3. Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase
4. A new model of binding of rifampicin and its amino analogues as zwitterions to bacterial RNA polymerase
5. Intramolecular proton transfer impact on antibacterial properties of ansamycin antibiotic rifampicin and its new amino analogues
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