A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix-Reference-Cited by-同舟云学术

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A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix

Published:2020 Issue:10 Volume:20 Page:1827-1844
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

van Dijk Christian G. M.¹²³⁴^ORCID,Brandt Maarten M.⁵⁶⁷⁸⁴,Poulis Nikolaos¹²³⁴,Anten Jonas¹²³⁴,van der Moolen Matthijs¹²³⁴,Kramer Liana¹²³⁴,Homburg Erik F. G. A.⁹¹⁰¹¹¹²¹³,Louzao-Martinez Laura¹²³⁴^ORCID,Pei Jiayi¹²³⁴,Krebber Merle M.¹²³⁴,van Balkom Bas W. M.¹²³⁴,de Graaf Petra¹⁴²³⁴^ORCID,Duncker Dirk J.⁵⁶⁷⁸⁴,Verhaar Marianne C.¹²³⁴^ORCID,Luttge Regina⁹¹⁰¹¹¹²¹³,Cheng Caroline¹²³⁴⁵

Affiliation:

1. Department of Nephrology and Hypertension

2. University Medical Center Utrecht

3. 3584 CX Utrecht

4. The Netherlands

5. Experimental Cardiology

6. Department of Cardiology

7. Thorax Center Erasmus University Medical Center

8. 3000 CA Rotterdam

9. Department of Mechanical Engineering

10. Microsystems Group

11. Materials Technology Institute (MaTe) and

12. ICMS Institute for Complex Molecular Systems

13. Eindhoven University of Technology

14. Department of Urology

Abstract

We present a microfluidic vascular device. Vascular cells in a 3D-ECM environment support hemodynamic flow and enable monocyte interaction.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Erasmus Medisch Centrum

Hartstichting

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/D0LC00059K

Reference96 articles.

1. A short discourse on vascular tissue engineering

2. The role of adherens junctions and VE-cadherin in the control of vascular permeability

3. ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

4. Monocytes Induce Reversible Focal Changes in Vascular Endothelial Cadherin Complex during Transendothelial Migration under Flow

5. How leukocytes cross the vascular endothelium

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