Microfluidic auto-alignment of protein patterns for dissecting multi-receptor crosstalk in platelets-Reference-Cited by-同舟云学术

Microfluidic auto-alignment of protein patterns for dissecting multi-receptor crosstalk in platelets

Published:2018 Issue:19 Volume:18 Page:2966-2974
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Zhou F.¹²³⁴,Chen Y.¹²³⁴⁵,Felner E. I.⁶⁷³⁴⁸,Zhu C.¹²³⁴⁵,Lu H.⁵²⁴⁸²^ORCID

Affiliation:

1. Woodruff School of Mechanical Engineering

2. Georgia Institute of Technology

3. Atlanta

4. USA

5. Interdisciplinary Program in Bioengineering

6. Division of Pediatric Endocrinology & Diabetes

7. Emory University

8. School of Chemical & Biomolecular Engineering

Abstract

We present a microfluidic system with precisely aligned ligand and antibody patterns to assay multi-ligand-receptor systems in cell adhension, using well controlled sequential cell-surface contacts.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2018/LC/C8LC00464A

Reference29 articles.

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3. Distinct Glycoprotein Ib/V/IX and Integrin αIIbβ3-dependent Calcium Signals Cooperatively Regulate Platelet Adhesion under Flow

4. P-Selectin Expression on Platelets Determines Size and Stability of Platelet Aggregates

5. SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

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