Comparative urine metabolomics of mice treated with non-toxic and toxic oral doses of (−)-epigallocatechin-3-gallate-Reference-Cited by-同舟云学术

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Comparative urine metabolomics of mice treated with non-toxic and toxic oral doses of (−)-epigallocatechin-3-gallate

Published:2023 Issue:20 Volume:14 Page:9434-9445
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Hwang Soomee¹^ORCID,Koo Imhoi²,Patterson Andrew D.²³,Lambert Joshua D.¹³^ORCID

Affiliation:

1. Department of Food Science, The Pennsylvania State University, 332 Food Science Building, University Park, PA 16802, USA

2. Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA

3. Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA

Abstract

The urine metabolite profiles of mice after oral dosing with non-toxic and toxic EGCG doses were compared. The observed change in EGCG biotransformation across doses may provide a better understanding of EGCG-mediated hepatotoxicity.

Funder

Pennsylvania State University

Agricultural Research Service

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO02710D

Reference39 articles.

1. Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis

2. Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: Dermal, acute and short-term toxicity studies

3. Fourteen-Week Toxicity Study of Green Tea Extract in Rats and Mice

4. Hepatotoxicity of high oral dose (−)-epigallocatechin-3-gallate in mice

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