Nanoparticle-based delivery systems as emerging therapy in retinoblastoma: recent advances, challenges and prospects

Author:

Onugwu Adaeze Linda1ORCID,Ugorji Onyinyechi Lydia2,Ufondu Chinasa A.3ORCID,Ihim Stella Amarachi4,Echezona Adaeze Chidiebere1,Nwagwu Chinekwu Sherridan1,Onugwu Sabastine Obinna5,Uzondu Samuel WisdomofGod6,Agbo Chinazom Precious1,Ogbonna John Dike1,Attama Anthony Amaechi17

Affiliation:

1. Drug Delivery and Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka, Enugu State, Nigeria

2. Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka, Enugu State, Nigeria

3. Molecular Pharmacology and Therapeutics, Department of Pharmacology, University of Minnesota, Twin Cities, USA

4. Department of Science Laboratory Technology (Physiology and Pharmacology Unit), University of Nigeria, Nsukka, Enugu State, Nigeria

5. Department of Pharmacognosy, Enugu State University of Science and Technology, Enugu State, Nigeria

6. NanoMalaria Research Unit, Drug Delivery and Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria Nsukka, Enugu State, Nigeria

7. Institute for Drug-Herbal Medicine-Excipient Research and Development, University of Nigeria Nsukka, Enugu State, Nigeria

Abstract

Nanoparticles utilized in targeting retinoblastoma cells demonstrated improved uptake and intracellular internalization, sustained retention, excellent cytotoxicity, enhanced apoptosis and improved antitumor activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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