Metal-free direct C-6–H alkylation of purines and purine nucleosides enabled by oxidative homolysis of 4-alkyl-1,4-dihydropyridines at room temperature-Reference-Cited by-同舟云学术

Metal-free direct C-6–H alkylation of purines and purine nucleosides enabled by oxidative homolysis of 4-alkyl-1,4-dihydropyridines at room temperature

Published:2023 Issue:8 Volume:21 Page:1744-1754
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Jiang Qingsong¹,Liu Xiguang¹,Wang Weili¹,Chen Yiwen¹,Yu Mingwu¹^ORCID

Affiliation:

1. School of Chemistry and Materials Science, Ludong University, Yantai 264025, Shandong Province, P. R. China

Abstract

The highly C6-regioselective alkylation of purines and purine nucleosidesviaoxidative homolysis of 4-alkyl-1,4-dihydropyridines at room temperature without metal catalysts and additional acids is reported for the first time.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB02070J

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