Isothermal kinase-triggered supramolecular assemblies as drug sensitizers-Reference-Cited by-同舟云学术

Isothermal kinase-triggered supramolecular assemblies as drug sensitizers

Published:2020 Issue:4 Volume:11 Page:1132-1139
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Dongdong¹²³⁴⁵,Miao Zhe¹²³⁴⁵,Wu Chengling¹²³⁴⁵,He Fangfei¹²³⁴⁵,Ren Peng⁶⁷⁴⁵,Bai Shuo⁶⁷⁴⁵^ORCID,Jiang Xingyu¹²³⁴⁵^ORCID,Gao Yuan¹²³⁴⁵^ORCID

Affiliation:

1. CAS Center for Excellence in Nanoscience

2. CAS Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety

3. National Center for Nanoscience and Technology

4. Beijing 100190

5. P. R. China

6. Institute of Process Engineering

7. Chinese Academy of Sciences

Abstract

A nonapeptide grafted LCST polymer undergoes enzymatic phosphorylation to assemble, which selectively disrupts PKA overexpressing cancer cells via kinetics targeting.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC04317A

Reference50 articles.

1. The Protein Kinase Complement of the Human Genome

2. Hallmarks of Cancer: The Next Generation

3. Issues and progress with protein kinase inhibitors for cancer treatment

4. Targeting protein kinases

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