Elucidating the role of surface chemistry on cationic phosphorus dendrimer–siRNA complexation

Author:

Deriu Marco A.12345,Tsapis Nicolas678910ORCID,Noiray Magali678910,Grasso Gianvito12345,El Brahmi Nabil117121314,Mignani Serge1516171819,Majoral Jean-Pierre117121314,Fattal Elias678910ORCID,Danani Andrea12345ORCID

Affiliation:

1. Istituto Dalle Molle di studi sull'Intelligenza Artificiale (IDSIA)

2. Scuola universitaria professionale della Svizzera italiana (SUPSI)

3. Università della Svizzera italiana (USI)

4. Manno

5. Switzerland

6. Institut Galien Paris-Sud

7. CNRS

8. Univ. Paris-Sud

9. Université Paris-Saclay

10. 92296 Châtenay-Malabry

11. Laboratoire de Chimie de Coordination

12. F-31077 Toulouse Cedex 4

13. France

14. Université de Toulouse

15. Laboratoire de Chimie et de Biochimie pharmacologiques et toxicologiques

16. CNRS UMR 860

17. Université Paris Descartes

18. PRES Sorbonne Paris Cité

19. Paris

Abstract

In the field of dendrimers targeting small interfering RNA (siRNA) delivery, dendrimer structural properties, such as the surface chemistry, play a crucial role in the efficiency of complexation.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

European Cooperation in Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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