Selective functionalization of the 1H-imidazo[1,2-b]pyrazole scaffold. A new potential non-classical isostere of indole and a precursor of push

Selective functionalization of the 1H-imidazo[1,2-b]pyrazole scaffold. A new potential non-classical isostere of indole and a precursor of push–pull dyes

Published:2021 Issue:39 Volume:12 Page:12993-13000
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Schwärzer Kuno¹,Rout Saroj K.¹,Bessinger Derya¹,Lima Fabio²,Brocklehurst Cara E.²,Karaghiosoff Konstantin¹^ORCID,Bein Thomas¹^ORCID,Knochel Paul¹^ORCID

Affiliation:

1. Department Chemie, Ludwig-Maximilians-Universität München, Munich 81377, Germany

2. Global Discovery Chemistry, Novartis Institutes of BioMedical Research, Basel 4057, Switzerland

Abstract

A methodology for the selective functionalization of the 1H-imidazo[1,2-b]pyrazole scaffold has been developed and used in the synthesis of novel push–pull dyes and a non-classical isostere of the indolyl drug pruvanserin.

Funder

Ludwig-Maximilians-Universität München

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC04155J

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