microRNA-181a silencing by antisense oligonucleotides delivered by virus-like particles-Reference-Cited by-同舟云学术

microRNA-181a silencing by antisense oligonucleotides delivered by virus-like particles

Published:2023 Issue:4 Volume:11 Page:816-825
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Chan Soo Khim¹,Steinmetz Nicole F.¹²³⁴⁵^ORCID

Affiliation:

1. Department of NanoEngineering, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA

2. Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA

3. Department of Radiology, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA

4. Center for Nano-ImmunoEngineering, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA

5. Center for Engineering in Cancer, Institute for Engineering in Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA

Abstract

Encapsulation of anti-miR-181a oligonucleotide into plant virus cowpea chlorotic mottle virus (CCMV) improves the stability of both RNA oligonucleotides. Knockdown efficacy was significantly improved with CCMV encapsulation compared to non-encapsulated counterpart.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2023/TB/D2TB02199D

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