Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats-Reference-Cited by-同舟云学术

Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats

Published:2013-05-28 Issue:6 Volume:5 Page:877-888
ISSN:1757-9708
Container-title:Integrative Biology
language:en
Short-container-title:

Author:

Geenen Suzanne¹²,Yates James W. T.³,Kenna J. Gerry⁴,Bois Frederic Y.⁵⁶,Wilson Ian D.²⁷,Westerhoff Hans V.¹⁸⁹

Affiliation:

1. Manchester Centre for Integrative Systems Biology and Doctoral Training Centre ISBML, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK

2. Drug Metabolism and Pharmacokinetics IM, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

3. Oncology iMED DMPK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

4. Global Safety Assessment, Innovative Medicines, AstraZeneca R&D, Alderley Park, Macclesfield, SK10 4TG, UK

5. Chair of Mathematical Modeling for Systems Toxicology, Université de Technologie de Compiègne, Royallieu Research Center, 60200 Compiegne, France

6. INERIS, 60550 Verneuil-en-Halatte, France

7. Dept of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College, Exhibition Rd, South Kensington, London, SW7 2AZ, UK

8. Molecular Cell Physiology, VU University, Amsterdam, The Netherlands

9. Systems and Synthetic Biology, FNWI, Universiteit van Amsterdam, The Netherlands

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

Link

http://academic.oup.com/ib/article-pdf/5/6/877/27452710/c3ib20245c.pdf

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4. Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis;Waters;J. Proteome Res.,2006

5. Induction of 5-oxoprolinuria in the rat following chronic feeding with N-acetyl 4-aminophenol (paracetamol);Ghauri;Biochem. Pharmacol.,1993

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