Moving perfusion culture and live-cell imaging from lab to disc: proof of concept toxicity assay with AI-based image analysis-Reference-Cited by-同舟云学术

Moving perfusion culture and live-cell imaging from lab to disc: proof of concept toxicity assay with AI-based image analysis

Published:2023 Issue:6 Volume:23 Page:1603-1612
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Serioli Laura¹²^ORCID,Gruzinskyte Lina³¹,Zappalà Giulia¹⁴^ORCID,Hwu En Te¹,Laksafoss Trygvi Zachariassen¹,Jensen Peter Lunding⁵,Demarchi Danilo⁴^ORCID,Müllertz Anette³¹^ORCID,Boisen Anja¹²,Zór Kinga¹²

Affiliation:

1. The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, Denmark

2. BioInnovation Institute Foundation, Copenhagen N 2800, Denmark

3. Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

4. Department of Electronics and Telecommunications, Politecnico di Torino, Italy

5. Cellari, ApS, Frederiksberg, Denmark

Abstract

We developed a compact perfusion cell culture with integrated wireless detection device for real-time optical monitoring. The platform enables long-term cell growth and cytotoxicity assay where cell viability is quantified using AI software.

Funder

Danmarks Grundforskningsfond

Villum Fonden

Novo Nordisk Fonden

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D2LC00984F

Reference58 articles.

1. Implementation and Use of State-of-the-Art, Cell-Based In Vitro Assays