Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR-Reference-Cited by-同舟云学术

Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR

Published:2019 Issue:69 Volume:9 Page:40336-40339
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Rolt Adam¹²³,O'Neill Paul M.⁴⁵⁶⁷³,Liang T. Jake⁸⁹¹⁰¹¹¹²,Stachulski Andrew V.⁴⁵⁶⁷³^ORCID

Affiliation:

1. Department of Biochemistry

2. University of Oxford

3. UK

4. The Robert Robinson Laboratories

5. Department of Chemistry

6. University of Liverpool

7. Liverpool

8. Liver Diseases Branch

9. National Institute of Diabetes and Digestive and Kidney Diseases

10. National Institutes of Health

11. Bethesda

12. USA

Abstract

The unusual α-amino, β-hydroxy acid MeBmt is a key structural feature of cyclosporin A, an important naturally occurring immunosuppressant and antiviral agent. We describe a concise synthesis of MeBmt using the principle of dynamic kinetic resolution.

Funder

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA08256E

Reference31 articles.

1. Stereoselective synthesis of unnatural (2S,3S)-6-hydroxy-4-sphingenine-containing sphingolipids

2. Unified Total Synthesis of Polyoxins J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions

3. Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5A

4. Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A

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