Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model-Reference-Cited by-同舟云学术

Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model

Published:2017 Issue:3 Volume:8 Page:1067-1079
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Tu Shih-Hsin¹²³⁴⁵,Chiou Yi-Shiou⁶⁷⁵⁸,Kalyanam Nagabhushanam⁹¹⁰¹¹,Ho Chi-Tang¹²¹³¹⁴¹¹,Chen Li-Ching¹⁵¹⁶⁵⁸¹⁷,Pan Min-Hsiung⁶⁷⁵⁸¹⁸^ORCID

Affiliation:

1. Department of Surgery

2. School of Medicine

3. College of Medicine

4. Taipei Medical University

5. Taipei

6. Institute of Food Science and Technology

7. National Taiwan University

8. Taiwan

9. Sabinsa Corporation

10. East Windsor

11. USA

12. Department of Food Science

13. Rutgers University

14. New Brunswick

15. Breast Medical Center

16. Taipei Medical University Hospital

17. TMU Taipei Cancer Center

18. Department of Medical Research

Abstract

Garcinol sensitizes breast cancer cells to Taxolviasynergistically inducing antimitotic effects and effectively repressing the activation of caspase-3/iPLA₂and Taxol-promoted NF-κB/Twist1 signaling pathways.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2017/FO/C6FO01588C

Reference66 articles.

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2. Breast cancer statistics, 2015: Convergence of incidence rates between black and white women

3. Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

4. Caspase-3 and prostaglandins signal for tumor regrowth in cancer therapy

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