Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin-Reference-Cited by-同舟云学术

Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

Published:2015 Issue:37 Volume:51 Page:7859-7862
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ma Rong¹²³⁴⁵,Wang Yiping⁶²³⁴,Yan Li⁷²³⁴,Ma Lili¹²³⁴⁵,Wang Zhigang¹²³⁴⁵,Chan Hoi Ching¹²³⁴,Chiu Sung-Kay⁶²³⁴,Chen Xianfeng⁷²³⁴,Zhu Guangyu¹²³⁴⁵

Affiliation:

1. Department of Biology and Chemistry

2. City University of Hong Kong

3. Kowloon Tong

4. Hong Kong SAR

5. City University of Hong Kong Shenzhen Research Institute

6. Department of Biomedical Sciences

7. Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science

Abstract

Co-delivery of a Pt(iv) prodrug and a p53 activator using layered double hydroxide (LDH) nanoparticles results in a significantly improved cell-killing effect.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC09879J

Reference24 articles.

1. The status of platinum anticancer drugs in the clinic and in clinical trials

2. Cellular processing of platinum anticancer drugs

3. The p53 Tumor Suppressor Gene: From Molecular Biology to Clinical Investigation

4. Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation

5. p53-dependent pathways of apoptosis

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