The first asymmetric total synthesis of lycoposerramine-R-Reference-Cited by-同舟云学术

The first asymmetric total synthesis of lycoposerramine-R

Published:2015 Issue:28 Volume:13 Page:7762-7771
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ishida Hiroaki¹²³⁴,Kimura Shinya¹²³⁴,Kogure Noriyuki¹²³⁴,Kitajima Mariko¹²³⁴,Takayama Hiromitsu¹²³⁴

Affiliation:

1. Graduate School of Pharmaceutical Sciences

2. Chiba University

3. Chiba 260-8675

4. Japan

Abstract

The first asymmetric total synthesis of lycoposerramine-R was accomplished by a strategy featuring the stereoselective intramolecular aldol cyclization giving a cis-fused 5/6 bicyclic skeleton and a new method for the construction of the pyridone ring via the aza-Wittig reaction, thereby establishing the absolute configuration of the natural product.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00827A

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