Label-free sensing of virus-like particles below the sub-diffraction limit by wide-field photon state parametric imaging of a gold nanodot array

Author:

Jin Xiao1ORCID,Zhang Heng1,Ni Bin1,Liu Weiping1,Hou Lianping2,Marsh John H.2ORCID,Ye Shengwei2,Sun Xiao2,Li Xiaofeng3,Li Shanhu4,Dong Lei5,Hou Jamie Jiangmin6ORCID,Sun Ming1,Xu Bin1,Xiong Jichuan1ORCID,Liu Xuefeng1ORCID

Affiliation:

1. School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China

2. James Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK

3. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, The first affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, P. R. China

4. Department of Cell Engineering, Beijing Institute of Biotechnology, Beijing, 100850, P. R. China

5. School of Life Science, Beijing Institute of Technology, Beijing 100081, P. R. China

6. The Royal College of Surgeons of Edinburgh, Nicolson Street, Edinburgh, Scotland, EH8 9DW, UK

Abstract

In this work we use a parallel four-quadrant sensing gold nanodot array to sense virus-like particles with a sub-diffraction limit size in a wide-field image. The label-free sensing of viruses enables the high-throughput onsite screening of viruses.

Funder

National Natural Science Foundation of China

Jiangsu Province Postdoctoral Science Foundation

Natural Science Foundation of Beijing Municipality

Fundamental Research Funds for the Central Universities

Ministry of Education of the People's Republic of China

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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