A synthesis, in silico, in vitro and in vivo study of thieno[2,3-b]pyridine anticancer analogues-Reference-Cited by-同舟云学术

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A synthesis, in silico, in vitro and in vivo study of thieno[2,3-b]pyridine anticancer analogues

Published:2015 Issue:11 Volume:6 Page:1987-1997
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Arabshahi Homayon J.¹²³⁴,van Rensburg Michelle¹²³⁴,Pilkington Lisa I.¹²³⁴⁵,Jeon Chae Yeon¹²³⁴,Song Mirae¹²³⁴,Gridel Ling-Mey¹²³⁴,Leung Euphemia⁵²⁴,Barker David¹²³⁴,Vuica-Ross Milena⁶⁷⁸,Volcho Konstantin P.⁹¹⁰¹¹¹²¹³,Zakharenko Alexandra L.¹⁴¹⁰¹¹¹²,Lavrik Olga I.¹³¹¹¹²¹⁴¹⁰,Reynisson Jóhannes¹²³⁴

Affiliation:

1. School of Chemical Sciences

2. University of Auckland

3. Auckland 1142

4. New Zealand

5. Auckland Cancer Society Research Centre and Department of Molecular Medicine and Pathology

6. Johns Hopkins University School of Medicine

7. Baltimore

8. USA

9. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry

10. Siberian Branch of the Russian Academy of Sciences

11. Novosibirsk

12. Russian Federation

13. Novosibirsk State University

14. Institute of Chemical Biology and Fundamental Medicine

Abstract

The thieno[2,3-b]pyridines bind to TDP1 with the best analogue 9d with IC₅₀ at 0.5 μM.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00245A

Reference45 articles.

1. The effect of PLC-γ2 inhibitors on the growth of human tumour cells

2. The development of thieno[2,3-b]pyridine analogues as anticancer agents applying in silico methods

3. Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives

4. The identification of novel PLC-γ inhibitors using virtual high throughput screening

5. Tumor Invasion: Role of Growth Factor-Induced Cell Motility

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3. New polyheterocycles derived from pyrano[4,3-b]thieno[3,2-e]pyridine;Russian Chemical Bulletin;2023-08

4. Synthesis and Anti-Proliferative Activity of 5-Benzoyl and 5-Benzylhydroxy Derivatives of 3-Amino-2-Arylcarboxamido-Thieno[2-3-b]Pyridines;International Journal of Molecular Sciences;2023-07-13

5. Synthesis of tetracyclic thienotriazolopyridines based on hydrazine derivatives of fused pyridinethiones;Russian Chemical Bulletin;2022-05

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