3′-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes
Author:
Affiliation:
1. Biomolecular Nanoscale Engineering Center
2. Department of Physics
3. Chemistry and Pharmacy
4. University of Southern Denmark
5. 5230 Odense M
Abstract
Synthesis of a novel 3′-pyrene-functionalized UNA monomer with unprecedented thermal stabilization of duplexes and triplexes.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02773C
Reference36 articles.
1. Synthesis and evaluation of oligodeoxynucleotides containing acyclic nucleosides: Introduction of three novel analogues and a summary
2. UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability
3. Pyrene-Modified Unlocked Nucleic Acids: Synthesis, Thermodynamic Studies, and Fluorescent Properties
4. Unlocked nucleic acid (UNA) and UNA derivatives: Thermal denaturation studies
5. Efficient RNase H-Directed Cleavage of RNA Promoted by Antisense DNA or 2‘F-ANA Constructs Containing Acyclic Nucleotide Inserts
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