Elusive structural changes of New Delhi metallo-β-lactamase revealed by ultraviolet photodissociation mass spectrometry-Reference-Cited by-同舟云学术

Elusive structural changes of New Delhi metallo-β-lactamase revealed by ultraviolet photodissociation mass spectrometry

Published:2020 Issue:33 Volume:11 Page:8999-9010
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Mehaffey M. Rachel¹²³⁴,Ahn Yeong-Chan⁵⁶²³⁴,Rivera Dann D.⁵⁶²³⁴,Thomas Pei W.⁵⁶²³⁴,Cheng Zishuo⁷⁸⁹⁴,Crowder Michael W.⁷⁸⁹⁴^ORCID,Pratt R. F.¹¹⁰¹¹⁴,Fast Walter⁵⁶²³⁴,Brodbelt Jennifer S.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Texas at Austin

3. Austin

4. USA

5. Division of Chemical Biology and Medicinal Chemistry

6. College of Pharmacy

7. Department of Chemistry and Biochemistry

8. Miami University

9. Oxford

10. Wesleyan University

11. Middletown

Abstract

We use mass spectrometry (MS) along with ultraviolet photodissociation (UVPD) to characterize structural variations in New Delhi metallo-β-lactamase (NDM) upon perturbation by ligands or mutation.

Funder

National Institutes of Health

Welch Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC02503H

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