A simple and feasible atom-precise biotinylated Cu(i) complex for tumor-targeted chemodynamic therapy

Author:

Luo Bi12345,Chen Liguang12345,Hong Zhaoguo12345,You Xin12345,Huang Fu-Ping12345ORCID,Bian He-Dong12345ORCID,Zhang Liangliang12345ORCID,Zhao Shulin12345ORCID

Affiliation:

1. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources

2. School of Chemistry and Pharmaceutical Sciences

3. Guangxi Normal University

4. Guilin 541004

5. P. R. China

Abstract

A simple and feasible atom-precise biotinylated Cu(i) complex, which can catalyze H2O2 overexpressed commonly in the tumor microenvironment to produce ˙OH through a Fenton-like reaction, was prepared and employed as an effective agent for tumor-targeted chemodynamic therapy.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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